Biochemical Laboratory Techniques

The Biochemical Standardization Laboratory

Laboratory of Biochemical Risk Analysis

We describe melphalan pharmacokinetics in 26 patients treated by isolated limb perfusion (ILP). Group A (n = 11) were treated with a bolus of melphalan (1.5 mg kg-'), and in a phase I study the dose was increased to 1.75 mg kg-'. The higher dose was given as a bolus to Group B (n = 9), and by divided dose to Group C (n = 6). Using high performance liquid chromatography (HPLC) the concentrations...

Experiments in Biochemical Research Techniques

mental data are given, the majority of these coming from agricultural experiments, but some being data from medical investigations. The book contains 17 chapters in all. The first three consist of an introduction, an account of methods of increasing the accuracy of experiments, and the review referred to above of methods of statistical analysis. The remaining 14 chapters give the detailed accou...

Biochemical laboratory management with a microcomputer

Efficient simulation techniques for biochemical reaction networks

Discrete-state, continuous-time Markov models are becoming commonplace in the modelling of biochemical processes. The mathematical formulations that such models lead to are opaque, and, due to their complexity, are often considered analytically intractable. As such, a variety of Monte Carlo simulation algorithms have been developed to explore model dynamics empirically. Whilst well-known method...